Synthetic Capsaicin

1.Product Name: Synthetic Capsaicin
2.Other Name：Nonivamide powder, Pelargonic acid vanillylamide, Synthetic N-Vanillylnonamide
3.Appearace: Off-white to white powder
4.Specification: ≥98% HPLC
5.CAS No.:2444-46-4
6.Scoville Heat Unit：16,000,000 SHU
7.Molecular formula:C17H27NO3
8.Melting Range: 55～61℃
9.Synthetic capsaicin Professional Manufacturer and Supplier
10.Solubility:Soluble in Chloroform, Ethanol & Insoluble in Water
11.Package: 1kg/Aluminum foil bag, 20Bags/Drum
12.Free Sample Available, COA,MSDS Available

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Synthetic Capsaicin Introduction

Synthetic Capsaicin also named Nonivamide is also called pelargonic acid vanillylamide or PAVA. It is a capsaicinoid. Nonivamide, isolated from peppers, is a naturally occurring analog of capsaicin (sc-3577). Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A. Nonivamide is with lower TRPV1 binding affinity, thus, a reduced pungency (9 200 000 scoville heat units) compared to capsaicin (16 000 000 scoville heat units).
Nonivamide is used in the food production to add a hot sensation to flavoring agents and spice mixtures. It is also used in the sweets and confectionary industries to add hot sensation into products. In pharmaceutical industries, nonivamide is used as a cheaper alternative for capsaicin. Warming or heating ointment of nonivamide is used for temporary relief of pain from conditions such as rheumatism, arthritis, lumbao, muscular aches, sprains and strains, sporting injuries and other conditions where local warmth is beneficial. Finalgon is one of the common product utilizing nonivamide for this purpose. Nonivamide is also used as an incapacitant spray, affecting the assailed person’s eyes, causing intense pain and swelling.

Shaanxi Rebecca Bio-Tech Co.,LTD, is the main Manufacturer of this synthetic capsaicin powder, Yearly production Quantity: 80 Tons,40% of our Production Quantity, are exported to Oversea Markets.Till Year 2023, we have been exporting it to over 18 countries in the world.Our Synthetic capsaicin has a chemical structure which is similar to natural capsaicin compounds and has similar biological activities as natural Capsaicin. But it has absolute advantages over natural capsaicin in terms of price and spiciness, so it has a much broader application fields.And we also provide free sample for you .Besides, our Synthetic Capsaicin is having the same function with Natural Capsaicin and higher Scoville Heat Units(SHU), because of its much lower price, It is supposed to replace natural Capsaicin in many industries, like food industry, medicine industry and other Industrial fields.
We look forward to hearing from you and establishing cooperation with you. If you have any questions about our products, you can contact us by information@sxrebecca.com at any time. We are happy to answer all your questions.

Certificate of Analysis

Item	Specification	Results
Appearance	Off-white to white Powder	White Powder
Assay of Synthetic Capsaicin	≥ 98%(HPLC)	99.13%
Decylic acid vanillylamide (N-VANILLYLDECANAMIDE)		0.65%
Vanillylamine hydrochloride (4-Hydroxy-3-methoxybenzylamine hydrochloride)		0.14%
Other similar alkalis		0.08%
Melting Range	55～61℃	58-59℃
Loss on drying	≤ 1.0%	0.18%
Heavy metal	≤ 5 ppm	0.0
Ignition residue	≤ 1.0%	0.17%
Solubility	Soluble in Chloroform, Ethanol & Insoluble in Water
Conclusion	Conforms with Company Standards

HPLC Chromatogram

Scoville Heat Unit or Scoville Hotness Units

Scoville designed a set of experimental methods called "Scoville Organoleptic test" to measure capsaicin content. This method is to dissolve one unit of capsaicin in the sugar water, and then give it to several people to taste, and then gradually increase the amount of sugar water until the spicy taste cannot be tasted. Scoville Hotness Units (SHU). For example, bell peppers have no spicy taste when eaten raw, so the SHU is 0~5; the SHU of allspice is between 100 and 500, which means that one unit of allspice requires 100~500 times of sugar water to neutralize. The substance with the highest SHU value is capsaicin, which

is around 15,000,000~16,000,000. Because this experimental method is greatly influenced by human subjectivity, later generations developed a method called "high performance liquid chromatography" (HPLC) to measure. However, because the Scoville indicator has been in use for a long time, the measurement value of high performance liquid chromatography is still often converted into SHU to represent the capsaicin content.

Nonivamide Chemical Properties

Melting point	54°C
Boiling point	200-210 °C(Press: 0.05 Torr)
density	1,1 g/cm³
FEMA	2787 \| NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
Fp	190°C
storage temp.	Sealed in dry,2-8°C
solubility	methanol: 100 mg/mL, clear to slightly hazy
form	powder
pka	9.76±0.20(Predicted)
color	white to off-white
Odor	bland odorless
Odor Type	bland
JECFA Number	1599
BRN	2144300
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	RGOVYLWUIBMPGK-UHFFFAOYSA-N
LogP	3.43
CAS DataBase Reference	2444-46-4(CAS DataBase Reference)
EPA Substance Registry System	Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- (2444-46-4)

Differences in the effects of synthetic capsaicin and natural capsaicin

Synthetic capsaicin Powder is a higher purity capsaicin with a stronger spicy taste and a longer-lasting anti-inflammatory and analgesic effect. At the same time, synthetic capsaicin has also been proven to have multiple functions such as anti-cancer and weight loss. Synthetic capsaicin is also widely used in the fields of capsaicin paint, rodent and insect repellent additives, etc.

Natural capsaicin is mainly made of peppers and is obtained through extraction, purification and other processes. In addition to its anti-inflammatory and analgesic effects, it can also promote gastric juice secretion, increase appetite, improve digestive function, promote blood circulation, lower cholesterol, control blood pressure, and prevent thrombosis. In addition, natural capsaicin is widely used in the fields of food and medicine, and its product added value is high.

In general, although both synthetic capsaicin and natural capsaicin have anti-inflammatory and analgesic effects, there are differences in their efficacy and uses in specific applications.

Product's Advantages

(1)It is in high purity and good quality with competitive price and wide usage.

(2)In industry, compared with the natural capsaicin, the product can lower the rawmaterial cost.

Usage

(1) Food Industry

In Some countries, like some Asia and Europe countries, synthetic capsaicin is listed as an approved Food Additive. So, It has been used in Food Industry for many years.

(2) Pharmaceutical Field

It has ideal functions of pain-relieve, anti-inflammatory, clearing meridian, activating collaterals, activating blood, and removing blood stasis. It can be made into sprays, liniments, tinctures, creams, patches,fever patches, etc. Which are for addiction-free analgesia, bacteria and fungi, promote circulation, etc. It has been widely used in External-use Medicines,like synthetic capsaicin ointment,External patchs, treatment of rheumatism, bruises, frostbite, antipruritic, antiseptic,anti-inflammatory and many other medicines.

(3) Biological Pesticides

The microemulsion made by synthetic capsaicin powder is a kind of plant-derived environmentally friendly biological insecticide. It has the characteristics of high efficacy, long lasting period, good safety, and no pollution to the environment. It is an ideal non-pollution pesticide.

(4) Anti-rat and Anti-ant repellent

It has a strong and long-lasting pungent taste, a small amount of addition can prevent rodents from chewing, and it can kill Termites, ants, so it is widely used in PE or PVC protective sheaths in cables and optical cables manufacturing fields. This application has been taken by cables and optical cables Manufacturers for many years.

(5) Pollution-free biological antifouling agent

Currently, as a Biological antifouling agent, it has been used in antifouling paints and coatings on ships, offshore platforms, and underwater facilities to prevent the adhesion of algae, shellfish, mollusks and other marine organisms, it can prevent the accumulation of aquatic organisms. It can replace toxic organic-tin antifouling agent.

（6）Military and self-protection fields

It has a strong sneezing effect, this can be used in some military.And self-protection products, like sprayer, etc.

The uses of synthetic capsaicin

1. Medical field: It can be used for non-addictive analgesia, inhibit bacteria and fungi, and promote blood circulation. It can be made into ointments, tinctures, creams, patches, etc., for the treatment of arthritis, muscle pain, back pain, neuralgia left over from sports sprains and other diseases.

2. Rat-proof cable materials: synthetic capsaicin powder is used as a rodent-proof additive for cable plastic sheaths to prevent animals from chewing and cutting, and is widely used in the cable and optical cable industries.

3. Biological antifouling agent: used in ship antifouling paint, applied to the parts of ships and offshore buildings that come into contact with seawater to prevent the attachment of marine organisms such as algae, shellfish, and mollusks.

4. Repellent: using the strong tear-inducing and sneezing effect of synthetic capsaicin, it is used to manufacture tear gas and other repellent equipment and personal defense products.

5. Biological pesticides: It is the main ingredient in the production of new green and environmentally friendly biological pesticides, which have the characteristics of high efficacy, long-lasting effect, good safety, and no pollution to the environment against order pests.

6. Drug addiction treatment: Drug addiction treatment injections made of high-purity synthetic capsaicin have a strong drug addiction treatment effect on all drug addictions.

7. Local weight loss: Synthetic capsaicin Powder can improve fat metabolism, consume excess fat, control weight, and achieve weight loss. It is especially suitable for patients with local obesity.

8. Treatment of skin diseases: such as stubborn psoriasis, urticaria, eczema, neurodermatitis, pruritus, and pruritus caused by hemodialysis.

9. Lowering cholesterol: It can promote blood circulation, accelerate blood purification, and promptly remove various toxins from the blood by promoting vasodilation, thereby lowering cholesterol, controlling blood pressure, and preventing thrombosis. It has a good effect on the prevention and treatment of hypertension and cardiovascular and cerebrovascular diseases.

10. Military use:It can be used in the military to make tear gas, tear gas guns, and defensive weapons.

Summary

The above are the main uses of synthetic capsaicin. It should be noted that although it has a wide range of uses, relevant safety regulations should be strictly observed during use to avoid unnecessary harm to the human body and the environment.

Packing

For powder products, we usually send the products together with cartons or fiber drums.For liquid products, we usually send the product together with a plastic.

Our packaging methods are 1 kg/aluminum bag, 25 kg/box, and 25 kg/barrel. For some products that require special packaging during transportation, we will carry out more detailed packaging.

Transportation

We support shipping by air, sea, FedEx, DHL, TNT, EMS, UPS, SF, and other carrier.

Our laboratory and Factory

As a professional plant extract supplier, our quality inspection department is equipped with the most advanced testing and identification instruments, such as UPLC, HPLC, UV and TT (active ingredients) GC and GC-MS (solvent residue), ICP-MS ( Heavy metals), GC/LC-MS-MS (pesticide residues), HPTLC and IR (identification), ELIASA (ORAC value), PPSL (irradiation residues), microbial detection, etc.

Shaanxi Rebecca Bio-Tech Co.,LTD, specializes in Research&Production on plant extracts, isolation of active ingredients of traditional Chinese medicine and functional compound formulations of traditional Chinese medicine. We have a high-quality technical R&D team with strong technical force, many experienced R&D personnel, an excellent marketing team and domestic regional channel partners. We specialize in product market development and product after-sales service, and are committed to serving customers all over the world. We provide high-quality natural herbal extracts to customers in the pharmaceutical, health care products, beverages, cosmetics and other industries.

At Rebecca, we follow market development trends and actively develop innovative products on the premise of continuity and diversity of herbal medicines. We believe that natural specialty ingredients and innovative technologies are the best basis for us to meet our customers' needs. There are other related high-quality products under our main categories, and we also support customized services.
As a professional manufacturer of Chinese plant and herbal extracts, we firmly believe that natural, healthy and functional products are our unremitting pursuit of excellence.

We are looking forward to working with you!!!

FAQ

Q:How do I make an order?

A: Simply contact our office by E-mail infomation@sxrebecca.com. We will connect you with one of our account managers who will be happy to assist you with your order.

Q: When will my order ship?

A: Products in stock usually ship within 24-48 hours of your order being received and processed. If a product is not in stock, delivery time varies but is generally about 3-5 days, depending on exact order quantity.

Q: How can I pay for my order?

A: We accept T/T(Telegraphic Transfer),L/C. etc.

Q: Do you test your products?

A: Yes, we test for all incoming raw materials before production of the extracts. Testing before any processing takes place helps us to deliver you the highest quality ingredients at the lowest possible prices.

Q: What is your Return Policy?

A: Your satisfaction is very important to us. If there are any problems with the product you receive, please contact your account manager within 10 days of receiving of your order. Upon receipt and inspection, Shaanxi Rebecca will issue a credit, refund or replacement.