Synephrine HCL Powder

Parameter	Specification
Active Ingredient	Synephrine Hydrochloride
Assay (HPLC)	≥98.0%
CAS Number	5985-28-4
Molecular Formula	C₉H₁₃NO₂·HCl
Molecular Weight	203.67 g/mol
Appearance	White to off-white crystalline powder
Mesh Size	80-200 mesh (customizable)
Solubility	Highly soluble in water, methanol, ethanol
Melting Point	150–152°C
pH Range (1% solution)	3.0–5.5
Heavy Metals	Pb <3ppm, As <1ppm, Cd <1ppm, Hg <0.1ppm
Shelf Life	24 months (sealed, cool, dark storage)
Test Item	Standard Requirement	Test Result	Judgment
Appearance	White or off-white crystalline powder, odorless	White crystalline powder, odorless	Complies
Identification	HPLC retention time & IR spectrum consistent with synephrine HCL reference standard	Conforms to reference substance	Complies
Assay (HPLC)	98.0% ~ 102.0%	99.53%	Complies
Loss on Drying	≤0.50%	0.21%	Complies
Residue on Ignition	≤0.10%	0.03%	Complies
Specific Optical Rotation [α]ᴅ²⁰	-47.0° ~ -52.0° (c=2, water)	-49.6°	Complies
pH (1% aqueous solution)	4.0 ~ 6.0	5.1	Complies
Related SubstancesSingle individual unknown impurityTotal impurities	≤0.10%≤0.30%	0.04%0.15%	CompliesComplies
Particle Size	100 mesh pass rate ≥98%	99.7%	Complies
Solubility	Freely soluble in water, soluble in methanol, slightly soluble in ethanol, insoluble in non-polar solvents	Conforms	Complies
Lead (Pb)	≤1.0 ppm	0.25 ppm	Complies
Arsenic (As)	≤1.0 ppm	Not Detected	Complies
Cadmium (Cd)	≤0.3 ppm	Not Detected	Complies
Mercury (Hg)	≤0.1 ppm	Not Detected	Complies
Residual Solvents	Meet ICH Q3C class 2 & 3 solvent limits	Complies	Complies
Total Aerobic Microbial Count	≤1000 CFU/g	52 CFU/g	Complies
Yeast & Mold Count	≤100 CFU/g	Not Detected	Complies
Escherichia coli	Negative per gram	Negative	Complies
Salmonella spp.	Negative per 25g	Negative	Complies
Staphylococcus aureus	Negative per gram	Negative	Complies

Excellent Raw Materials: Only fresh immature Citrus aurantium from approved plantations in Hunan, Jiangxi, Sichuan and Mexico are used by us. Pharmaceutical grade material is made from the full young fruit with tight controls on pesticide / heavy metal. Organic grade alternatives are grown without pesticides and are USDA certified with separate manufacturing lines to avoid cross contamination.

Superior Production Capacity: Equipped with 3 dedicated GMP-compliant lines and an annual production of more than 2,000 tons, we provide over 100 botanical extract variations to customers across the globe.

State of the Art Testing Laboratory UPLC, HPLC, GC-MS, ICP-MS and LC-MS-MS are in our laboratory. Full COA with HPLC chromatograms, heavy metal scans, pesticide residue reports and microbiological testing for every batch. Third party validation is accessible via SGS/Eurofins.

Global Certifications: ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER, NOP, EOS, cGMP for easy regulatory compliance in US, EU and Asian markets.

Origin: GAP controlled plantings young bitter orange fruit We do not accept fallen, rotten or over ripe fruit. HPLC baseline screening indicates that the native alkaloid concentration is 0.5–0.8% prior to processing.

Grade Classification:

· Pharmaceutical/High-Purity: Freshly harvested whole fruit for 98% monomer

· Nutraceutical: Quality-controlled crushed fruit for 5%, 6%, 30% extracts

· Organic: USDA-certified, zero-pesticide cultivation with full traceability

Solubility: Very soluble in cold/hot water, methanol, ethanol; insoluble in mineral oils. For ointments dissolve in propylene-glycol prior.

Stability Profile:

· Temperature: Stable ≤60°C; degradation above 80°C

· pH: Optimal 3.0–5.5; degrades in alkaline environments

· Light: Dry Synephrine HCL Powder stable; aqueous solutions yellow under prolonged UV

· Hygroscopicity: 98% purity shows minimal moisture absorption. Store sealed at <25°C, <60% RH

Raw Material Sorting: HPLC screening; remove defective fruit; pesticide/heavy metal pre-test
Drying & Grinding :45–50°C low-temp drying; 20–30 mesh coarse powder
Acid Extraction :0.05–0.1M HCl, 50–55°C, 2hr + 1.5hr dual extraction
Filtration: Bag + ultrafiltration membrane to remove pectin/protein
Resin Enrichment: Cation exchange resin adsorbs synephrine; alkaline elution
Salt Formation: pH 3.5–4.0 HCl acidification; activated carbon decolorization
Crystallization (98%) :0–5°C crystallization; dual ethanol recrystallization
Spray Drying (5–30%) :Inlet 145°C, outlet 70°C; 80-120 mesh
QC Testing : HPLC, ICP-MS, GC-MS; COA + MSDS issuance
Key Control: Temperature ≤60°C throughout to preserve alkaloid integrity.

· ISO9001, FSSC22000, HALAL, KOSHER, NOP, cGMP Certification Matrix

· Complete Traceability: Batch to batch documentation from planting to final product

· Third Party Testing: Validated by SGS, Eurofins

· Tests: HPLC purity, heavy metals, pesticide residues, solvents, microbiological limits

· Uniformity: Batch RSD <2 % for uniform content

Packing: 1kg aluminum foil bag / 25kg fiber drum (PE vacuum inner bag)

Custom Options: Private label Dosage Forms: Tablets, Capsules, Synephrine HCL Powder sachets

Shipping Methods: FedEx, DHL, air freight, sea freight depending on the order quantity and destination

Q: What test method confirms purity?

A: We employ USP compliant reversed-phase HPLC with complete chromatogram data. Third-party retest supported.

Q: Which spec suits sports nutrition products?

A: 30% for pre-workouts, greatest cost performance for weight reduction. 98% for medications, premium formulae.

Q: Can it withstand high-temperature processing?

A: Stable at ≤60 °C. Do not go over 80°C, since this will degrade alkaloids. pH stability: 3.0-5.5.

Q: Does it clump during shipping?

A: 98% higher purity resists moisture All batches are packaged in vacuum sealed aluminum foil bags to avoid caking in humid circumstances.

Q: What's your MOQ and lead time?

A: Sample MOQ 1kg; Production MOQ 25kg+ Lead time 7-15 days ex-works.

Ready to source reliable, traceable Synephrine HCL Powder for your formulations? Reach out to our team at information@sxrebecca.com