Diosmin
Botanical Source:Citrus aurantium L.
Other Name：Citrus aurantium Extract，Citrus aurantium extract powder， Diosmin powder，Diosmin 90%，Diosmin 90% powder，Diosmin EP，Diosmin EP11，Diosmin Micronized Powder, Diosmin 5 microns powder, 520-27-4.
Active ingredients：Diosmin
Specification：90%
Standard :EP, BP, USP, Micronized, DC
Appearance: Greyish-yellow or light yellow powder
Test Method: HPLC
Solubility: Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%), it dissolves in dilute solution of alkali hydroxides
Part Used：Immature fruit
CAS No.: 520-27-4
Molecular Formula: C28H32O15
Molecular Weight：608.54
MOQ: 1kg
Sample: 20g
Delivery: FedEx, DHL, Ship by air, Ship by sea.
Certifications: ISO, HACCP, KOSHER, HALAL
Basic introduction
Diosmin is a semisynthetic flavonoid molecule derived from Citrus aurantium L.(modified hesperidin).
The product is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is often taken in combination with hesperidin.
Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States
why choose us?
Diverse Product Range: We offer a wide variety of products and a full range of specifications.
Customization: We offer OEM (Original Equipment Manufacturer) and ODM (Original Design Manufacturer) services, allowing you to customize the appearance and functionality of your products to your brand's needs, contributing to your brand's success.
Innovation and Quality: All our products are manufactured using advanced technology, high-quality materials, strict production controls, state-of-the-art production equipment, and a rigorous and meticulous quality assurance system to meet the high standards of our global customers.
Global Supply Chain: Our robust global supply chain network enables us to quickly respond to market demands and provide timely delivery services to support your business growth.
Customer-centric: Our customers' needs are our top priority. We are committed to providing you with the best products and the highest level of service. From pre-sales consultation to after-sales support, we strive for excellence at every stage.
Technical Data Sheet
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Item |
Specification |
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Assay of Diosmin |
90.0%~102.0% |
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Physical Control |
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Appearance |
Greyish-yellow or light yellow, hygroscopic powder |
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Odor |
Typical |
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Taste |
Typical |
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Particle size |
NLT95% below 5 microns |
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Loss on drying |
≤5.0% |
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Sulphated Ash |
≤0.2% |
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Solubility |
Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%), it dissolves in dilute solution of alkali hydroxides |
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Identification |
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A |
IR: Complies diosmin CRS |
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B |
HPLC: Complies to the reference solution |
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Iodine |
≤0.1% |
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Related Substances |
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Impurity A(Acetoisovanillone) |
≤0.5% |
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Impurity B(Hesperidin) |
≤4.0% |
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Impurity C(Isorhoifolin) |
≤3.0% |
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Impurity D(6-iododiosmin) |
≤0.6% |
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Impurity E (Linarin) |
≤3.0% |
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Impurity F(Diosmetin) |
≤2.0% |
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Unspecified Impurities(each) |
≤0.4% |
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Total Impurities |
≤8.5% |
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Residual Solvents |
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Pyridine |
≤200ppm |
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Heavy Metals |
≤10ppm |
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Pb |
＜3ppm |
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As |
≤1ppm |
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Cd |
≤1ppm |
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Hg |
≤0.1ppm |
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Country of Origin |
China |
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Allergens |
None |
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Cross-allergens |
Not available |
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Shelf Life |
2 Years from Manufacture Date. |
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Irradiation |
Non-Irradiation |
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GMO |
Non-GMO |
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Grade |
Food Grade |
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Pesticides |
Residual Pesticides Conforms to EC 396/2005 |
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Microbiological |
Total Plate Count |
＜1000cfu/g |
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Mould and Yeast |
＜100cfu/g |
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E.Coli |
Negative |
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Salmonella |
Negative |
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Staphylococcus Aureus |
Negative |
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Biological Properties
Antioxidant:
Diosmin is a potent antioxidant that scavenges free radicals, which helps to mitigate oxidative stress in various tissues and diseases, including diabetic complications and inflammatory conditions.
Anti-inflammatory:
It reduces the production of pro-inflammatory cytokines (like TNFα, IL-1β, IL-6), inhibits leukocyte recruitment and activation, and modulates inflammatory signaling pathways, such as NF-κB.
Anticancer:
Diosmin has demonstrated anticancer potential by promoting apoptosis (programmed cell death) in cancer cells, inhibiting angiogenesis (formation of new blood vessels), and interfering with metastasis.
Antidiabetic:
The compound improves glucose homeostasis and insulin sensitivity, helping to manage diabetes and its associated complications, such as neuropathy.
Anti-ulcer:
Diosmin shows therapeutic potential for antiulcer effects, contributing to gastrointestinal health.
Antibacterial:
It possesses antibacterial properties that can inhibit the growth of bacteria by disrupting their cell membrane structures and interfering with quorum sensing mechanisms.
Neuroprotective:
Diosmin protects nerve cells from oxidative stress and inflammation, playing a role in promoting nerve regeneration, particularly in conditions like diabetic neuropathy.
Vascular Protection:
In the context of chronic venous insufficiency, diosmin helps improve lymphatic function, reduces microvascular permeability by inhibiting leukocyte adhesion, and decreases pressure within lymphatic vessels.
Application
Medical field: Diosmin is mainly used in the medical field to treat chronic venous diseases, such as varicose veins and hemorrhoids. It can enhance the resistance of the blood vessel walls, improve blood circulation, reduce edema and pain. In addition, Diosmin is also used to treat chronic lymphedema and capillary fragility syndrome.
Cosmetics Field: In the cosmetics industry, diosmin is highly favored due to its antioxidant and anti-inflammatory properties. It can promote the synthesis of collagen, enhance skin elasticity, and reduce the formation of wrinkles. Additionally, diosmin can also improve skin microcirculation, increase skin nutrient supply, and enhance skin vitality. The application of diosmin in anti-aging cosmetics is becoming increasingly widespread, especially in anti-wrinkle, whitening, and moisturizing aspects, where it performs exceptionally well.
Food Additives: Diosmin can also be used as a food additive to enhance the color, flavor and nutritional value of food. Due to its natural origin and biological activity, Diosmin is regarded as a safe and healthy food additive.
Shipping and Packaging
We offer flexible shipping options to meet your needs, with packaging available in 1kg, 5kg, and 25kg containers. All products are vacuum-sealed in food-grade packaging to ensure freshness and potency.
Our laboratory and Factory
As a professional plant extract supplier, our quality inspection department is equipped with the most advanced testing and identification instruments, such as UPLC, HPLC, UV and TT (active ingredients) GC and GC-MS (solvent residue), ICP-MS ( Heavy metals), GC/LC-MS-MS (pesticide residues), HPTLC and IR (identification), ELIASA (ORAC value), PPSL (irradiation residues), microbial detection, etc.
Shaanxi Rebecca Bio-Tech Co.,LTD, specializes in Research&Production on plant extracts, isolation of active ingredients of traditional Chinese medicine and functional compound formulations of traditional Chinese medicine. We have a high-quality technical R&D team with strong technical force, many experienced R&D personnel, an excellent marketing team and domestic regional channel partners. We specialize in product market development and product after-sales service, and are committed to serving customers all over the world. We provide high-quality natural herbal extracts to customers in the pharmaceutical, health care products, beverages, cosmetics and other industries.
At Rebecca, we follow market development trends and actively develop innovative products on the premise of continuity and diversity of herbal medicines. We believe that natural specialty ingredients and innovative technologies are the best basis for us to meet our customers' needs. There are other related high-quality products under our main categories, and we also support customized services.
As a professional manufacturer of Chinese plant and herbal extracts, we firmly believe that natural, healthy and functional products are our unremitting pursuit of excellence.
We are looking forward to working with you!!!
Qualification Certification
Contact Us
For inquiries, samples, or to discuss your specific needs, please email us at information@sxrebecca.com. Our team of experts is ready to support your Diosmin requirements and help bring your innovative products to market.
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