Nicotinamide riboside chloride
Other Name：nicotinamide riboside powder
Active ingredients：Nicotinamide riboside chloride
Specification：Min 98%
Appearance: White Powder
Test Method: HPLC
Solubility: Nicotinamide ribose chloride is soluble in water.
Molecular Formula: C11H15ClN2O5
Molecular weight:290.7
CAS No.: 23111-00-4
MOQ: 1kg
Sample: 20g
Delivery: FedEx, DHL, Ship by air, Ship by sea.
Certifications: ISO, HACCP, KOSHER, HALAL
Basic introduction
Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
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1. Professional Manufacturer.
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5. 13 years Professional and efficient import and export experiences.
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7. Flexible transportation methods: DHL/FEDEX/By AIR/By Sea.
8. Professional service before and after sales.
Certificate of analysis
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ITEMS |
SPECIFICATIONS |
RESULTS |
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Appearance |
Off-white to white powder |
Conforms |
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Structure |
NMR |
Conforms |
|
Purity（HPLC） |
≥98.0% |
99.88% |
|
Water |
≤0.5% |
0.06% |
|
Bulk density |
0.3-0.8g/ml |
0.63g/ml |
|
Heavy Metals |
Pb＜1ppm |
Conforms |
|
Cd＜1ppm |
Conforms |
|
|
Hg＜0.1ppm |
Conforms |
|
|
As＜1ppm |
Conforms |
|
|
Residual Solvents |
Methanol：≤3000PPM |
Conforms |
|
Acetone：≤5000PPM |
Conforms |
|
|
Total Microbial Count |
＜1000cfu/g |
Conforms |
|
Yeasts&Molds |
＜1000cfu/g |
Conforms |
|
E．Coll |
Negative |
Conforms |
|
Salmonella |
Negative |
Conforms |
|
S. Aureus |
Negative |
Conforms |
|
Shelf life |
2 Years when properly storage. |
|
|
Packing |
Packed in 25kgs or 30kgs fiber drums. |
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Storage conditions |
To be stored in tightly sealed and preferable full containers in cool, dry and ventilated area; Protect from heat and light sources. |
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Test Conclusion |
Conforms to Enterprise standard. |
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Biological Properties
Nicotinamide riboside chloride (NRCl) is a stable, water-soluble form of vitamin B3 that serves as a precursor to nicotinamide adenine dinucleotide (NAD+). As an NAD+ booster, its primary biological role is to elevate NAD+ levels, which are crucial for cellular energy metabolism, DNA repair, and cellular signaling. This effect leads to benefits such as improved mitochondrial function, increased SIRT activity, and potential protection against age-related decline and various diseases. NRCl is generally considered safe for human use as a dietary supplement, with research ongoing to fully characterize its therapeutic potential.
Mechanism of Action
NAD+ Precursor:
NRCl is a form of vitamin B3 that is metabolized to generate NAD+ in mammalian cells.
Cellular Energy:
NAD+ is a critical coenzyme for cellular respiration, a process that generates ATP, the primary energy source for cells.
Sirtuin Activation:
NAD+ is required by sirtuins (SIRTs), a group of enzymes that regulate gene expression, DNA repair, and other cellular functions.
Mitochondrial Function:
Increased NAD+ levels through NRCl supplementation can improve mitochondrial function and support cellular health.
Biological Benefits
Energy Metabolism:
By boosting NAD+ and supporting ATP production, NRCl influences energy metabolism.
Neuroprotection:
Studies suggest NRCl may help mitigate age-related cognitive decline and has shown potential in models of neurodegenerative diseases.
Regenerative Potential:
It has been linked to the regenerative potential of stem cells and may support muscle health.
Anti-inflammatory Effects:
NRCl has been shown to decrease levels of pro-inflammatory cytokines, potentially offering protective effects in various inflammatory conditions.
HPLC Chromatogram
NON-Allergen
|
Allergenic Compounds |
Status（Yes/No） |
|
Mollusc |
No |
|
Eggs |
No |
|
Fish |
No |
|
Lupin |
No |
|
Soya |
No |
|
Milk |
No |
|
Peanuts |
No |
|
Gluten |
No |
|
Crustaceans |
No |
|
Mustard |
No |
|
Nuts |
No |
|
Sesame |
No |
|
Celery |
No |
|
Sulphites |
No |
Synthetic Route
Function
1.Enhance energy metabolism: Nicotinamide riboside chloride can be converted into NAD+ (nicotinamide adenine dinucleotide), which is an important coenzyme within cells and participates in various cellular metabolic processes, including energy production, DNA repair, cell proliferation, etc. During the aging process of the human body, the content of NAD+ gradually decreases. The supplementation of nicotinamide riboside chloride can increase the level of NAD+, which is expected to delay cellular aging and the occurrence of related diseases.
2. Enhance endurance and athletic performance: Nicotinamide riboside chloride can enhance energy metabolism, thereby improving endurance and athletic performance.
3. Enhance neural function and memory: Nicotinamide riboside chloride can improve neural function and memory by influencing synaptic transmission and brain function.
4. Enhancing the function of the immune system: Nicotinamide riboside chloride can stimulate macrophages to produce interferon, thereby enhancing the body's ability to fight against viruses and achieving the goal of improving immunity.
5. Improve sleep quality: Nicotinamide riboside chloride has central nervous system activity. It can inhibit excessive excitement in the central nervous system and alleviate insomnia symptoms caused by stress or anxiety, thereby helping to improve sleep quality.
6. Protecting heart health: Nicotinamide riboside chloride can lower the level of low-density lipoprotein cholesterol, prevent the occurrence and development of atherosclerosis, and thereby maintain the normal operation of the cardiovascular system.
7. Promote growth and development: Nicotinamide riboside chloride participates in the synthesis process of various biological macromolecules in the body, such as nucleic acids and proteins, which play a crucial role in cell division and proliferation. Therefore, it can have a certain effect of promoting growth and development.
Application
Nicotinamide ribose chloride (NR-CL) can be used as a dietary supplement.
(NR-CL) can be used as a cosmetic raw material.
It can be used as a food additive.
Stability
Nicotinamide ribose chloride has good stability and can maintain its activity and efficacy under different environmental and storage conditions.Nicotinamide Riboside Chloride (NR for short) is a derivative of vitamin B3 and a new type of bioactive substance. It is composed of a sugar molecule, ribose, and a vitamin B3 component, nicotinamide (also known as niacin or vitamin B3), and can be obtained by consuming foods such as meat, fish, and grains or through NR supplements. Nicotinamide ribose chloride can be converted into NAD+ (nicotinamide adenine dinucleotide) and exert biological activity within cells. NAD+ is an important coenzyme within cells, participating in various cellular metabolic processes, including energy production, DNA repair, and cell proliferation. During the aging process of the human body, the content of NAD+ gradually decreases. Supplementation with nicotinamide riboside chloride can increase the level of NAD+, which is expected to delay cellular aging and the occurrence of related diseases
Solubility
Solubility in Water
- High solubility: A study published in the National Institutes of Health (NIH) found NRCl to be freely soluble in water at pH 2.0, 5.0, and 7.4, with concentrations of 972.7 ± 8.1 mg/mL, 860.5 ± 31.0 mg/mL, and 826.0 ± 34.4 mg/mL, respectively, based on USP definitions.
- Lower solubility: However, other sources from product datasheets indicate a much lower water solubility, such as around 10 mg/mL in Phosphate Buffered Saline (PBS) at pH 7.2 for Cayman Chemical and approximately 58 mg/mL for Selleckchem.
Solubility in Other Solvents
- DMSO: NRCl has limited solubility in dimethyl sulfoxide (DMSO), with one source stating approximately 58 mg/mL.
- Ethanol: It is insoluble in ethanol.
Factors Affecting Solubility
Intrinsic instability: NRCl's solubility in water is limited by its intrinsic instability in aqueous solutions, which makes it unsuitable for ready-to-drink beverages and high-moisture foods.
pH dependency: There is some pH-dependent solubility, with higher solubility at lower pH values.
Moisture absorption: The solubility of NRCl can decrease if DMSO becomes moisture-absorbing.
Packing
For powder products, we usually send the products together with cartons or fiber drums.Our packaging methods are 1 kg/aluminum bag, 25 kg/box, and 25 kg/barrel. For some products that require special packaging during transportation, we will carry out more detailed packaging.
Transportation
We support shipping by air, sea, FedEx, DHL, TNT, EMS, UPS, SF, and other carrier.
Our laboratory and Factory
As a professional plant extract supplier, our quality inspection department is equipped with the most advanced testing and identification instruments, such as UPLC, HPLC, UV and TT (active ingredients) GC and GC-MS (solvent residue), ICP-MS ( Heavy metals), GC/LC-MS-MS (pesticide residues), HPTLC and IR (identification), ELIASA (ORAC value), PPSL (irradiation residues), microbial detection, etc.
Contact us
To view our brochure or discuss a bulk order, contact us at information@sxrebecca.com.
FAQ
How do I make an order?
For Further Information, please contact: information@sxrebecca.com. We will connect you with one of our account managers who will be happy to assist you with your order.
When will my order ship?
Products in stock usually ship within 24-48 hours of your order being received and processed. If a product is not in stock, delivery time varies but is generally about 3-5 days, depending on exact order quantity.
What is your Return Policy?
Your satisfaction is very important to us. If there are any problems with the product you receive, please contact your account manager within 10 days of receiving of your order. Upon receipt and inspection, Shaanxi Rebecca will issue a credit, refund or replacement.
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