Synthetic Curcumin

【English name】: Synthetic Curcumin
【CAS No.】: 458-37-7
【Molecular Formula】: C21H20O6
【Active ingredients】: Synthetic Curcumin
【Specification】: Synthetic Curcumin 98%
【Appearance】: Yellow-Orange powder
【Melting Point】: 183 ℃
【Water soluble】: Slightly soluble
【Stability】: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

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Natural Turmeric Curcumin Powder ...

Synthetic Curcumin – Pure Lab-Crafted Curcuminoid for Precision Applications

Synthetic Curcumin is a laboratory-engineered curcuminoid passed on through aldol condensation of vanillin and acetylacetone underneath stomach settling operator conditions, publicizing you a single-molecule, high-purity elective to conventional turmeric extracts. Not at all like plant-derived curcumin—a three-component blend (curcumin, demethoxycurcumin, and bisdemethoxycurcumin)—this chemically synthesized shape passes on ≥98% faultless curcumin monomer, free from agrarian contaminations. You choose up full clump consistency, zero pesticide or overpowering metal threats, and evaluating unaffected by climate or collect instabilities. Its shinning brilliant appearance, uniform composition, and exceptional relentlessness make the thing idealize for pharmaceutical rough materials, high-end skincare subtle elements, standardized prosperity supplements, and consistent examine where correct dosing and reproducibility are non-negotiable.

Why Choose Our Synthetic Curcumin?

Chemical Synthesis for Unmatched Purity

Our thing begins from controlled chemical condensation, not turmeric roots. You get a single curcumin monomer—no demethoxy analogs, no plant arrange, no normal changeability. This ensures:

l Pesticide-Free & Heavy-Metal-Free: No agrarian contamination

l Batch-to-Batch Consistency: Steady color, substance, and performance

l Cost Consistency: Free of trim disappointments or agriflation

Superior Stability & Clarity

Compared to natural extracts, the product exhibits:

· Lower Hygroscopicity: Resists moisture absorption and color darkening

· High Solution Clarity: Bright golden liquid, no turbidity

· Light & Heat Resistance: Stable at ≤100℃, shelf life 24 months when stored sealed, cool, and dark

Precision Dosing for Targeted Applications

Single-ingredient composition enables correct anti-inflammatory and antioxidant effects—perfect for:

· Pharmaceutical intermediates

· Clinical inquire about protocols

· High-requirement send out markets (EU/US standards)

· Food coloring (E100) and premium beauty care products

Products Description

Test Item	Standard Requirement	Test Result	Judgment
Appearance & Odor	Orange-yellow crystalline powder; Slightly characteristic odor, tasteless	Orange-yellow crystalline powder, slight characteristic odor, tasteless	Complies
Solubility	Practically insoluble in water, soluble in glacial acetic acid and chloroform, slightly soluble in ethanol	Conforms to standard solubility characteristics	Complies
Identification	Shall comply with the exclusive identification reaction and infrared spectrum identification of curcumin	Complies	Complies
Curcumin Content (HPLC)	98.0% - 102.0% (Calculated on dried basis)	99.32%	Complies
Loss on Drying	≤0.5%	0.18%	Complies
Residue on Ignition	≤0.1%	0.04%	Complies
Heavy Metals (as Pb)	≤10ppm	2.8ppm	Complies
Arsenic (As)	≤2ppm	Not Detected	Complies
Related Substances (Impurities)	Single unknown impurity ≤0.1%, Total impurities ≤0.3%	Single maximum impurity: 0.05%, Total impurities: 0.15%	Complies
Particle Size	80-120 mesh pass rate ≥98%	100 mesh pass rate: 99.6%	Complies
Microbial Limit	Total Aerobic Bacteria ≤1000cfu/g, Molds & Yeasts ≤100cfu/g, No E. coli & Salmonella	Total Aerobic Bacteria: 72cfu/g, Molds & Yeasts: Not Detected, No Pathogenic Bacteria	Complies

Technical Specifications

Parameter	Value
CAS No.	458-37-7
Molecular Formula	C₂₁H₂₀O₆
Molecular Weight	368.38 g/mol
Purity	≥98% (HPLC)
Appearance	Bright yellow-orange powder
Melting Point	183°C
Water Solubility	≤0.1 μg/mL (25℃)
Ethanol Solubility	10–20 mg/mL
Acetone Solubility	≥50 mg/mL
DMSO Solubility	≥100 mg/mL
pH Stability	3–6 (acidic environment)
Storage	Sealed, light-protected, ≤25℃
Shelf Life	24 months

Solubility & Stability Guide

Solubility (Highly Lipophilic)

· Water: Nearly insoluble; somewhat solvent in hot water

· Ethanol/Methanol: Dissolvable (10–20 mg/mL)

· Acetone/Ethyl Acetic acid derivation: Effectively dissolvable (≥50 mg/mL)

· DMSO/Glacial Acidic Corrosive: Amazingly solvent (≥100 mg/mL)

Stability Factors

· pH: Steady pH 3–6; debases and discolors (reddish-brown) over pH 7

· Temperature: Steady ≤100℃; moderate deterioration >120℃

· Light: Sensitive—store absent from light

· Metal Particles: Complexes with Fe³⁺, Cu²⁺—avoid contact

Production Process Overview

1. Crude Fabric Pretreatment: Decontaminate vanillin and acetylacetone

2. Boron Complexation: Acetylacetone + boric anhydride complex formation

3. Aldol Condensation: Controlled-temperature response builds Manufactured Curcumin structure

4. Acid Hydrolysis: Discharge unrefined curcumin through weaken acid

5. Crystallization & Washing: Expel salts and impurities

6. Recrystallization: Separate 95%/98%/99% purities by cycle count

7. Vacuum Drying: 50–60℃, light-protected, pulverized to fine powder

8. QC & Bundling: Fixed in light-proof sacks, tried to USP/FCC measures

Synthetic vs. Natural Curcumin

Aspect	Synthetic Curcumin	Natural Curcumin
Raw Material	Vanillin + acetylacetone (chemical)	Turmeric rhizome (plant)
Composition	Single curcumin monomer	3-component mixture
Purity	≥98%, batch-stable	75–95%, variable
Impurities	Zero pesticide/heavy metals	Prone to agricultural residues
Color	Bright golden yellow	Darker yellowish-brown
Stability	Low hygroscopicity, light-resistant	Higher hygroscopicity, oxidizes easily
Applications	Pharma, research, standardized products	Herbal supplements, organic foods

Key Applications

· Pharmaceutical Rough Materials: Correct anti-inflammatory and antioxidant agent

· High-End Skincare: No botanical allergens, consistent color

· Food Coloring (E100): Uniform pigmentation, heat-stable

· Standardized Nutraceuticals: Redress dosing for clinical efficacy

· Scientific Ask around: Reproducible comes approximately, zero C14 carbon

Quality Assurance

Certifications: ISO9001, HALAL, Legitimate, cGMP, ISO22000, FSSC22000, HACCP, Non-GMO, Vegan

Testing Capabilities:

· HPLC purity assay (≥98%)

· Residual solvent analysis (USP <467>)

· Heavy metals (ICP-MS): Pb <3ppm, As <1ppm

· Radiocarbon (C14) testing to confirm synthetic origin

· Third-party verified for potency and safety

Flexible Packaging & Custom Solutions

Standard Packaging:

· 1 kg aluminum foil bags

· 25 kg cartons/drums

Custom Options:

· Tailored formulations (powder, tablets, capsules)

· OEM/ODM services

· Light-protected, export-grade packaging

FAQ

Q: Is the thing as compelling as common curcumin in antioxidant and anti-inflammatory tests?

A: Unadulterated curcumin monomers offer more grounded centering on and relentless, controlled pointers underneath standard test conditions. Characteristic three-component curcumin appears synergistic impacts with wealthier by and huge activity, so you can select based on your formulation's ampleness goals.

Q: Do differing immaculateness grades (95%, 98%, 99%) impact photostability?

A: Yes. Higher ethicalness infers less contaminations, coming approximately in slower oxidation and discoloration underneath light. Our 98% and 99% grades show up through and through prevalent photostability than 95%, making them culminate for things with tall appearance standards.

Q: Are amalgamation unrefined materials constrained, and appear dangerous intermediates remain in the wrapped up product?

A: All unrefined materials comply with mechanical controls. Our multi-step filtration plan totally controls center and by-product buildups interior widespread limits. Wrapped up things pass various security tests for EU and US markets.

Q: Does high-purity thing lose development in the midst of high-temperature emulsification or sprinkle drying?

A: Activity mishap is irrelevant underneath standard dealing with underneath 100℃. Warm robustness is marvelous. As long as deferred ultra-high-temperature introduction is avoided, it alters well to most food and therapeutic taking care of.