
Trilobatin Powder
Storage type:Cool and dry place
specification:25kg/bag
Shelf life:24 Months
additive:Food additive
content:>98%
CAS number:4192-90-9
Molecular formula:C21H24O10
Application field:Food, toothpaste, cosmetics, feed, sweeteners, and the medical field, etc.
Certification:Kosher, Halal, ISO9001, ISO14001, ISO22000, FSSC22000, IP, NON-GMO.
Premium Trilobatin Powder | 98% Natural Sweetener & Metabolic Support Ingredient
Trilobatin Powder is a natural dihydrochalcone glycoside isolated from the tender leaves of Lithocarpus polystachyus. We are a competent ingredient provider and we understand your formulation challenges: clean-label sweetness with retained bioactivity, batch-to-batch consistency and tight export compliance regulations. Our 98% criterion provides steady purity and low color fluctuation, which is a key need for overseas oral health supplements and popular whitening essences. This premium component addresses major industry challenges such as control of glucose metabolism, antioxidant protection, and natural sweetness satisfaction, while offering excellent solubility and stability in a range of dosage forms.
Technical Specifications of Trilobatin Powder
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Parameter |
Standard |
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CAS No. |
4192-90-9 |
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Molecular Formula |
C₂₁H₂₄O₁₀ |
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Molecular Weight |
436.41 g/mol |
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Active Content |
Trilobatin ≥ 98.0% |
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Appearance |
White to off-white crystalline powder |
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Particle Size |
80–100 mesh / 200 mesh (customizable) |
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Moisture Content |
≤ 5.0% |
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Heavy Metals |
≤ 10 ppm |
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Pesticide Residues |
Compliant with EU/USP standards |
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Microbiological |
Total Plate Count ≤ 1000 CFU/g |
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| Test Item | Standard Requirement | Test Result | Judgment |
|---|---|---|---|
| Appearance | White to off-white crystalline powder, odorless |
White to off-white crystalline powder |
Complies |
| Identification | HPLC retention time & UV spectrum consistent with Trilobatin reference standard | Positive match with reference standard | Complies |
| Assay (HPLC) | 98.0% ~ 102.0% | 99.41% | Complies |
| Loss on Drying | ≤0.50% | 0.23% | Complies |
| Residue on Ignition | ≤0.10% | 0.03% | Complies |
| Single Unknown Impurity | ≤0.10% | 0.04% | Complies |
| Total Related Impurities | ≤0.30% | 0.14% | Complies |
| Particle Size | 100 mesh pass rate ≥98% | 99.7% | Complies |
| Solubility | Slightly soluble in cold water, soluble in hot water, ethanol, methanol and propylene glycol | Conforms to solubility property | Complies |
| Lead (Pb) | ≤1.0 ppm | 0.22 ppm | Complies |
| Arsenic (As) | ≤1.0 ppm | Not Detected | Complies |
| Cadmium (Cd) | ≤0.3 ppm | Not Detected | Complies |
| Mercury (Hg) | ≤0.1 ppm | Not Detected | Complies |
| Residual Solvents | Meet ICH Q3C residual solvent limits | Complies | Complies |
| Total Aerobic Microbial Count | ≤1000 CFU/g | 42 CFU/g | Complies |
| Yeast & Mold Count | ≤100 CFU/g | Not Detected | Complies |
| Escherichia coli | Negative per gram | Negative | Complies |
| Salmonella spp. | Negative per 25g | Negative | Complies |
| Staphylococcus aureus | Negative per gram | Negative | Complies |
Why Choose Us
Research and Development Team: Our dedicated researchers are experts in plant extraction, with years of experience in flavonoid separation and cyclodextrin modification, innovating to satisfy increasing market needs.
Large-Scale Capacity: We run three specialized manufacturing lines that produce over 2,000 tons a year, ensuring a stable supply for your enterprises across the world.
Full-Scale Testing Laboratory: Fast, accurate quality checks on every batch with our state-of-the-art UPLC, HPLC, GC-MS, ICP-MS and pesticide residue analyzers.
Certified Quality Systems: ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER and cGMP certifications provide globally recognized quality standards.
bespoke Formulations for Powder, Tablet, Hard Capsule & Soft Capsule Formats :We can develop a bespoke formulation for your application requirements.

Source & Traceability
Core Extraction Raw Materials: We source exclusively from first-harvest Lithocarpus spp. tender leaves harvested in spring. Old leaves, withered branches, moldy materials, and insect-damaged parts are strictly removed. Post-harvest, raw materials undergo rapid low-temperature drying (40–45℃) to prevent sunlight oxidation that degrades flavonoid content.
Grade Classification:
· High-Purity Refined Grade (98%): First-harvest tender buds undergo full heavy metal and pesticide residue screening before processing. This grade features low background impurities and is produced on independent lines to prevent cross-contamination—specifically designed for export markets.
· Traceable Export Grade: Complete planting, harvesting, and processing traceability with origin data available. Independent production lines ensure zero cross-contamination with conventional raw materials.

Solubility & Stability
Trilobatin Powder (Standard): Slightly soluble in cold water, soluble in hot water, ethanol, methanol and acetone. Almost insoluble in vegetable oils. (Do not add to vegetable oils) Crystallising and dispersing poorly when introduced at high quantities immediately to oil phases.
Cyclodextrin-modified version: Easily soluble in both cold and hot water to provide homogenous transparent solutions that do not become murky or precipitate on standing – the choice for clear essences, oral liquids and cleared drinks.
Thermal Stability: Stable during vacuum drying at low temperature (≤65℃). Prolonged exposure to high heat might cause some deterioration.
Light & Oxygen Sensitivity: Vacuum packed in light resistant aluminum foil pouches to ensure glycoside integrity and prevent oxidation.

Manufacturing Process
Step 1 – Raw Material Pretreatment Impurities are removed by manual and air sorting, then the material is dried with low temperature hot air (40-45℃). Materials are ground to 20 to 30 mesh to improve the contact area with the solvent.
Step 2 – Ethanol Reflux Extraction: Closed reactor extraction with food grade ethanol aqueous solution 2-3 times. Plate and frames filtration for solid-liquid separation.
Step 3 – Low-Temperature Concentration: Under negative pressure (<65℃), concentrate extract with ethanol recovery for recycling.
Step 4 - Macroporous resin purification: Diluted extract was placed onto columns of resin. Sugars, pigments and salts are washed by water. Trilobatin is enriched by ethanol gradient elution.
Step 5 – Recrystallization & Purification Specification 98%: Double recrystallization with activated carbon decolorization and two-stage resin purification can effectively eliminate flavonoid impurities and pigments, and the purity is constant and the color difference between batch is small.
Step 6 – Rinsing & Vacuum Drying: The crystals were washed with weak ethanol and filtered water, centrifuged for dehydration and vacuum dried in darkness (≤65℃) to avoid oxidation.
Step 7-Optional Cyclodextrin Modification: Mix high-purity trilobatin with β-cyclodextrin by high-pressure homogenization, spray dry to get cold-water-soluble modified powder.
Step 8 – Grinding & 3D Mixing: Grinding to required particle sizes and blending in 3D mixers to achieve homogenous content, color and particle dispersion.
Step 9 - Sealed Packaging & Testing: Vacuum packed in aluminium foil bags, secured in 25kg moisture resistant cardboard barrels. Heavy metals and microbial testing prior to storage , full content .

Applications & Benefits
Metabolic Health Supplements: Supports modification of glucose metabolism for weight management tablets, capsules and meal replacement powders.
Whitening & Anti-Aging Cosmetics: With constant purity and uniform color, 98% Trilobatin Powder is the standard option for whitening essences, anti-aging serums and high-end skincare formulas.
Oral Care Products: A natural sweetener with bioactive qualities, perfect for chewable pills, lozenges and oral care supplements.
Functional Beverages: Offers natural sweetening and antioxidant advantages for health beverages, sports nutrition and clarifying beverages.

Quality Assurance
Certification Systems ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER, cGMP, Non-GMO, Vegan
Testing Capabilities: Each batch is evaluated for purity, potency, heavy metals, pesticide residues and microbiological by UPLC, HPLC, ICP-MS and GC-MS.
Traceability: Complete documentation from the procurement of raw materials to the final product distribution provides complete transparency of the supply chain.
Third Party Validation: Independent laboratory testing results are available upon request.

Packaging & Delivery
Standard Packaging: 1 kg aluminum foil bags; 25 kg cartons; 25 kg fiber drums with moisture-proof liners.
Customized Options: Flexible packaging solutions available for specialized transportation and storage requirements.
Shipping Methods: Air freight and ocean freight options; worldwide supply capabilities with professional logistics support.

FAQ
Q: Do you test raw materials for heavy metals and pesticide residues before processing?
A: Yeah. We utilize only recently picked fresh delicate leaves and do not use rotting, worm-eaten or damaged material. All source materials undergo tested for complete pesticide residue and heavy metals before feeding. Unqualified batches are rejected immediately.
Q: What’s the difference between 95%, 98% and 99% specifications?
A: 95% single recrystallization (inexpensive for basic skin care and meal replacements); 98% double recrystallization with decolorization (most common for oral supplements and whitening essences); 99% repeated gradient recrystallization and chromatographic purification (premium dietary formulations and pharmaceutical intermediates).
Q: Can I put regular trilobatin straight into oil-based creams?
A: Slightly soluble in vegetable oils. Crystallization may be caused by direct high dosage addition. Emulsifiers should be pre-dissolved in ethanol or propylene glycol to provide a uniform distribution into the oil phase.
Q: Do you have cyclodextrin modifications in water soluble forms?
Yes. Our β-cyclodextrin inclusion modified product is meant to dissolve quickly in cold and hot water to provide clear solutions. It is specifically developed for use in transparent essences, oral liquids and clarified beverage formulations.
Q: What is your minimum order quantity and lead time?
A: MOQ is adjustable as per specification. Standard lead time 10-15 days following order confirmation. For bespoke needs, please contact us at information@sxrebecca.com.
Contact Us
Ready to elevate your Trilobatin Powder formulation? Contact Shaanxi Rebecca Bio-Tech today at information@sxrebecca.com for samples, technical data sheets, and customized solutions tailored to your specific application needs.








